A GC–FID method for quantitative analysis of N,N-carbonyldiimidazole

• Rapid and robust GC–FID based method of CDI analysis is presented.
• Protocol involves a quick and simple derivatization of CDI with methanol.
• Method has been validated and is easily transferable.

N,N-Carbonyldiimidazole (CDI), a common synthetic reagent used in commercial scale pharmaceutical synthesis, is known to be sensitive to hydrolysis from ambient moisture. This liability demands a simple, robust analytical method to quantitatively determine reagent quality to ensure reproducible performance in chemical reactions. This work describes a protocol for a rapid GC–FID based analysis of CDI.

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