کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1221036 1494630 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Raman imaging of pharmaceutical materials: Refractive index effects on contrast at buried interfaces
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Raman imaging of pharmaceutical materials: Refractive index effects on contrast at buried interfaces
چکیده انگلیسی


• Raman resolution targets were fabricated to mimic pharmaceutical materials.
• Reflection at the PEG/PDMS interface contributes to the Raman signal.
• Model based on geometric optics was developed to simulate the image functions.
• Results emphasize the influence of refractive index discontinuities.
• Findings have impact on interpretation of Raman images of pharmaceutical samples.

Resolution targets composed of bilayer polydimethylsiloxane (PDMS) devices with buried polyethylene glycol (PEG) channels have been fabricated using traditional photolithographic and micromolding techniques to develop resolution targets that mimic pharmaceutical materials. Raman chemical images of the resulting PEG-in-PDMS devices composed of varying parallel line widths were investigated by imaging the PEG lines through a thin overlayer of PDMS. Additionally, a scattering agent, Al2O3, was introduced at varying concentrations to each layer of the device to explore the effects of scattering materials on Raman images. Features in the resulting chemical images of the PEG lines suggest that reflection at the PEG/PDMS interface contributes to the Raman signal. A model based on geometric optics was developed to simulate the observed image functions of the targets. The results emphasize the influence of refractive index discontinuities at the PEG/PDMS interface on the apparent size and shape of the PEG features. Such findings have an impact on interpretation of Raman images of nonabsorbing, opaque pharmaceutical samples.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 105, 25 February 2015, Pages 17–23
نویسندگان
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