کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1221154 | 967815 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Analysis of co-spray-dried meloxicam–mannitol systems containing crystalline microcomposites Analysis of co-spray-dried meloxicam–mannitol systems containing crystalline microcomposites](/preview/png/1221154.png)
The crystal size, form, wettability and rate of dissolution of a drug are factors limiting its nasal or pulmonary administration. The aim of this work was to achieve an ideal crystal habit, good wettability and the rapid release of meloxicam (MEL), a poorly water-soluble non-steroidal anti-inflammatory drug. The structures of MEL and the carrier-based systems were analysed by differential scanning calorimetry, X-ray diffractometry and Fourier transform infrared spectroscopy. The particle size and morphology were investigated by laser diffraction and SEM analyses. The novelty of this work was the use of a co-spray-drying technique, which resulted in mannitol-based crystalline microcomposites (1–6 μm) containing MEL microcrystals (1–5 μm). The particle size and form of the MEL microcrystals were adjusted by a top-down method. The presence of mannitol (with a MEL:mannitol mass ratio of 1:1) with additives ensured the homogeneous distribution of MEL in the microcomposites with good wettability and rapid release (100% MEL within 5 min).
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 56, Issue 2, 10 September 2011, Pages 183–190