کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1221394 1494634 2014 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls
ترجمه فارسی عنوان
رویکردهای تحلیلی برای تشخیص داروهای در حال ظهور و داروهای غیر تایید شده در کنترل دوپینگ انسان
کلمات کلیدی
دوپینگ ورزش، طیف سنجی جرمی، داروهای نوظهور، استامولوآمب، آنتی بادی ضد میواستاتین
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• A review of non-approved/discontinued drugs relevant for doping controls is presented.
• Substances arguably affecting skeletal muscle and oxygen transport capacities are discussed.
• Analytical aspects of low and high molecular mass compounds in the light of modern sports drug testing programs are outlined.
• Relevant representatives of drug classes and mass spectral data are summarized.

The number and diversity of potentially performance-enhancing substances is continuously growing, fueled by new pharmaceutical developments but also by the inventiveness and, at the same time, unscrupulousness of black-market (designer) drug producers and providers. In terms of sports drug testing, this situation necessitates reactive as well as proactive research and expansion of the analytical armamentarium to ensure timely, adequate, and comprehensive doping controls. This review summarizes literature published over the past 5 years on new drug entities, discontinued therapeutics, and ‘tailored’ compounds classified as doping agents according to the regulations of the World Anti-Doping Agency, with particular attention to analytical strategies enabling their detection in human blood or urine. Among these compounds, low- and high-molecular mass substances of peptidic (e.g. modified insulin-like growth factor-1, TB-500, hematide/peginesatide, growth hormone releasing peptides, AOD-9604, etc.) and non-peptidic (selective androgen receptor modulators, hypoxia-inducible factor stabilizers, siRNA, S-107 and ARM036/aladorian, etc.) as well as inorganic (cobalt) nature are considered and discussed in terms of specific requirements originating from physicochemical properties, concentration levels, metabolism, and their amenability for chromatographic-mass spectrometric or alternative detection methods.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 101, December 2014, Pages 66–83
نویسندگان
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