کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1221755 1494643 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization of stress degradation products of fosinopril by using LC-MS/TOF, MSn and on-line H/D exchange
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Characterization of stress degradation products of fosinopril by using LC-MS/TOF, MSn and on-line H/D exchange
چکیده انگلیسی


• Forced degradation studies were carried out on fosinopril.
• LC-MS tools were used for characterization of its degradation products.
• Mass fragmentation profiles were established for the drug and degradation products.
• Degradation pathway of the drug was laid down.

Fosinopril was subjected to stress degradation studies under hydrolytic (acidic, basic and neutral), oxidative, photolytic and thermal stress conditions. The drug underwent degradation in hydrolytic and photo acidic conditions, while it was stable to oxidative and thermal stress. The degradation products (DPs) were detected after using a gradient LC-MS method. These were characterized using a protocol involving comparison of mass fragmentation pathways of the drug and the DPs, and consideration of mass data generated during MS/TOF, MSn and H/D exchange studies. The degradation pathway of the drug was established, which was duly justified by mechanistic explanation.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 92, 15 April 2014, Pages 135–143
نویسندگان
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