کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1222095 1494673 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Homogeneity study of ointment dosage forms by infrared imaging spectroscopy
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Homogeneity study of ointment dosage forms by infrared imaging spectroscopy
چکیده انگلیسی

Ointment dosage forms are semi-solid preparations intended for local or transdermal delivery of active substances usually for application to the skin and it is important that they present a homogeneous appearance. In this work, a study of the homogeneity of a tacrolimus ointment dosage form was performed using infrared imaging spectroscopy coupled with principal component analysis (PCA) and multivariate curve resolution with alternating least squares (MCR-ALS) to interpret the imaging data. Optical visible microscopy images indicated possible phase separation in the ointment and, based on the results presented by distribution concentration maps from infrared imaging, it was possible to conclude that, in fact, there was phase separation incorporated in the ointment. Thus, infrared imaging spectroscopy associated to PCA and MCR-ALS is demonstrated to be a powerful tool for the development process of ointment dosage forms.


► Study of the homogeneity of a tacrolimus ointment dosage form was performed using infrared imaging spectroscopy.
► Principal component analysis (PCA) and multivariate curve resolution were used to interpret the imaging data.
► Distribution concentration maps from infrared imaging was obtained.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 58, 25 January 2012, Pages 42–48
نویسندگان
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