کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1222482 1494672 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of a novel sildenafil analogue in an adulterated herbal supplement
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Identification of a novel sildenafil analogue in an adulterated herbal supplement
چکیده انگلیسی

iErect, a new dietary supplement marketed as “100% natural” and sold over the Internet, was analyzed. It contains thiosildenafil, a sildenafil analogue already reported as an adulterant in herbal formulations, and a new compound whose structure was elucidated after isolation using NMR, MS and IR. It was named depiperazinothiosildenafil as it results from the hydrolytic cleavage of the S–N bond of the sulfonamide group of thiosildenafil. A capsule of iErect contains a very high amount (≈220 mg) of thiosildenafil and ≈30 mg of depiperazinothiosildenafil, which places consumers at risk for potentially serious side-effects.


► iErect is a new dietary supplement “100% natural” sold over the Internet.
► It contains thiosildenafil and a new analog named depiperazinothiosildenafil.
► LC–MSn, accurate mass, NMR and IR were used to characterize the new analog.
► A capsule contains ≈220 and ≈30 mg of thiosildenafil and depiperazinothiosildenafil.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 59, 5 February 2012, Pages 58–66
نویسندگان
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