کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1222701 967870 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Establishing the carbon skeleton of pharmaceutical agents using HSQC-ADEQUATE spectra
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Establishing the carbon skeleton of pharmaceutical agents using HSQC-ADEQUATE spectra
چکیده انگلیسی

Two-dimensional NMR methods are the cornerstone of modern structure elucidation methods. When the ensemble of 1D and 2D NMR experiments normally employed for structure assignment fails, investigators typically resort to successively more complex 2D NMR experiments for structure determination and/or spectral assignment. Unsymmetrical Indirect Covariance (UIC) NMR data processing methods provide a convenient and highly efficient means of accessing the connectivity information embodied in more complex experiments such as HSQC-TOCSY spectra. Using Unsymmetrical Indirect Covariance (UIC) or General Indirect Covariance (GIC) processing to mathematically combine multiplicity-edited GHSQC and 1,1-ADEQUATE 2D NMR spectra affords an HSQC-ADEQUATE spectrum that offers a new method for establishing the carbon skeleton of a molecule. The application of this technique is demonstrated for a novel cyclin-dependant kinase inhibitor, Dinaciclib™ (SCH 727965).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 55, Issue 5, 15 July 2011, Pages 895–901
نویسندگان
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