کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1222803 | 967871 | 2008 | 4 صفحه PDF | دانلود رایگان |
S(−)-Satropane is currently being developed to in situ forming ophthalmic gel, a new ophthalmic delivery system, for the treatment of glaucoma. To evaluate the pharmacokinetic profiles of S(−)-satropane, the microdialysis method was employed. The concentration of S(−)-satropane in dialysates was measured by using liquid chromatography/tandem mass spectrometry (LC–MS/MS). Unlike the common solution prepared in normal saline, in which the level of S(−)-satropane in aqueous humor increased rapidly after instillation and reached the maximal level (Cmax of 1.508 ± 0.297 μg ml−1) within 1 h, S(−)-satropane exhibited 3.2-fold greater Cmax and 2.2-fold greater AUC0–3h (p < 0.05) in the in situ forming gel. The results showed that the in situ forming gel system could improve the ocular bioavailability of S(−)-satropane.
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 48, Issue 3, 4 November 2008, Pages 840–843