کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1222981 1494676 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Electrocatalytic activity of 4-nitrophthalonitrile-modified electrode for the l-glutathione detection
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Electrocatalytic activity of 4-nitrophthalonitrile-modified electrode for the l-glutathione detection
چکیده انگلیسی

The present work describes the substantial electrocatalytic activity of (NC)2C6H3–NHOH/(NC)2C6H3–NO redox couple-modified electrode toward the low voltage detection of l-glutathione (GSH), in neutral medium, at an applied potential of 0.4 V versus Ag/AgCl. After optimizing the operational conditions, the sensor provided a linear response range for GSH from 8.0 up to 83.0 μmol L−1 with sensitivity, detection and quantification limits of 54 nA L μmol−1, 2.7 μmol L−1 and 8.0 μmol L−1, respectively. The proposed sensor presented higher sensitivity when compared to other modified electrodes described in the literature and showed a stable response for at least 100 successive determinations. The repeatability of the measurements with the same sensor and different sensors, evaluated in terms of relative standard deviation, were 4.1 and 5.0%, respectively, for n = 10. The developed sensor was applied for GSH determination in yeast extract and the results were statistically the same with those obtained by the comparative method described in the literature at a confidence level of 95%.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 47, Issues 4–5, 5 August 2008, Pages 758–764
نویسندگان
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