کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1223152 967883 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Compatibility of atenolol with excipients: LC–MS/TOF characterization of degradation/interaction products, and mechanisms of their formation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Compatibility of atenolol with excipients: LC–MS/TOF characterization of degradation/interaction products, and mechanisms of their formation
چکیده انگلیسی

A study was carried out to investigate compatibility of atenolol, a β1 blocker, with a variety of pharmaceutical excipients. The binary mixtures (1:1) of atenolol with the excipients were stored for 1 month at 40 °C/75% RH. The samples were directly observed for the physical changes, and also analyzed by a validated HPLC method to determine the chemical changes. The study revealed that atenolol was incompatible with ascorbic acid, citric acid and butylated hydroxyanisole. The degradation/interaction products formed in these mixtures were characterized by high resolution mass spectrometric and fragmentation analyses, using a LC–MS/TOF system. The identity of characterized structures was justified through mechanistic explanations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 49, Issue 4, 1 May 2009, Pages 880–888
نویسندگان
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