کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1223160 967883 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The stability of biapenem and structural identification of impurities in aqueous solution
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
The stability of biapenem and structural identification of impurities in aqueous solution
چکیده انگلیسی

The stability of biapenem in aqueous solution was investigated. Forced degradation of biapenem was carried out under different concentrations, pH values and temperatures. The degradation products were determined by reverse-phase HPLC and identified by LC–MS/MS. One dimeric impurity was obtained by reverse-phase preparative HPLC and characterized by LC–MS/MS and NMR. A possible degradation mechanism has been presented.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 49, Issue 4, 1 May 2009, Pages 937–944
نویسندگان
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