کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1223203 967884 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural elucidation of a process-related impurity in ezetimibe by LC/MS/MS and NMR
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Structural elucidation of a process-related impurity in ezetimibe by LC/MS/MS and NMR
چکیده انگلیسی

A major process-related impurity associated with the synthesis of ezetimibe was detected by LC–MS. The isolated impurity was found not to have been previously reported. Based on LC/MS/MS studies and accurate mass data, the structure of that impurity was proposed to be 2-(4-hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide. The postulated structure was unambiguously confirmed with the help of the NMR and IR analyses of a synthetically obtained sample. The chemical shift of the labile proton of that new entity was assigned by a 2D-NOESY NMR experiment. A rationalization for the formation of this impurity is provided.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 52, Issue 1, 1 May 2010, Pages 73–78
نویسندگان
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