کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1223292 967887 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Profile of nitric oxide (NO) metabolites (nitrate, nitrite and N-nitroso groups) in honeys of different botanical origins: Nitrate accumulation as index of origin, quality and of therapeutic opportunities
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Profile of nitric oxide (NO) metabolites (nitrate, nitrite and N-nitroso groups) in honeys of different botanical origins: Nitrate accumulation as index of origin, quality and of therapeutic opportunities
چکیده انگلیسی

Besides dermoprotective activity, honey also has a strong gastroprotective effect, from salivary reduction of nitrate (NO3−) to nitrite (NO2−) and intragastric formation of nitric oxide (NO), this lastly involved in the preservation of the gastric mucosa capillaries and in boosting mucous production. Aim of this work is to profile the distribution of NO metabolites (NO3−, NO2− and total N-nitroso-groups, N-NO) in a set of honeys (n = 54) of different botanical origins, using a chemiluminescence based technique (NO-analyzer, NOA). All the honeys contained appreciable amounts of NO3− (from 1.63 ± 0.04 to 482.98 ± 5.34 mg/kg), the highest in honeydew honeys (10–40 times than in nectar honeys). Low levels of NO2− were found in all samples (0.01 ± 0.00 to 0.56 ± 0.01 mg/kg). N-NO groups, at trace levels in some nectar honeys, were higher in honeydew samples (from 0.01 ± 0.00 to 0.29 ± 0.01 mg/kg). Total phenol content (TP) and total protein (TProt) were comparable to those in literature. Multivariate analysis indicated that N-NO groups were significantly associated with NO2− and TP thus to suggest an in situ environmental nitrosation of specific nitrosable substrates (lysine, proline) favored by high reducing conditions. The bee-smoking process can be an alternative or complementary explanation for N-NO contamination. Hence NO3− rich honeys intake may exert beneficial effects against NSAIDs-induced gastric injury. Finally NO3− is a potential reliable marker of a honey's origin and quality.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 53, Issue 3, 2 November 2010, Pages 343–349
نویسندگان
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