کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1224268 967917 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparative isolation and structural elucidation of impurities in fluconazole by LC/MS/MS
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Preparative isolation and structural elucidation of impurities in fluconazole by LC/MS/MS
چکیده انگلیسی

Three impurities were detected in the LC/MS analysis of fluconazole bulk drug substance. Two of the impurities were unknowns having not been reported previously. Structural assignment of these impurities was carried out by LC/MS/MS using electrospray ionization source and an ion trap mass analyzer. Structural elucidation using nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy was facilitated by newly developed rapid preparative isolation method. These impurities were characterized as 1-(1-H-1,2,4-triazole-1-yl) propane-2,3-diol and Z-2-(2,4-difluorophenyl)-3-(1-H-1,2,4-triazole-1-yl)-2-propen-1-ol. Their formation and synthesis are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 42, Issue 3, 26 September 2006, Pages 334–340
نویسندگان
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