کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1224309 967918 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Buprenorphine assay and plasma concentration monitoring in HIV-infected substance users
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Buprenorphine assay and plasma concentration monitoring in HIV-infected substance users
چکیده انگلیسی
A chromatographic method for monitoring BUP and its active metabolite, NBUP was investigated. An assay was developed that would facilitate BUP and ARV measurement from a single 3 mL blood sample (0.75 mL plasma required) in conjunction with a previously validated multiple ARV HPLC method. The method measures BUP and NBUP over the range from 0.25 to 50 ng/mL with mass spectrometry detection. Inter- and intra-assay variation was ≤11%, across the concentration range. The method quantitates BUP and NBUP plasma concentrations within the range of expected values from current BUP dosing guidelines. Use of this combined BUP and ARV plasma concentration monitoring approach for a representative patient receiving BUP, atazanavir and efavirenz demonstrated its clinical application.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 44, Issue 1, 9 May 2007, Pages 188-195
نویسندگان
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