کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1224529 | 1494677 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Isolation and identification of novel impurities in spironolactone
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Three known and five new steroidal compounds as impurities in spironolactone were isolated from the enriched mother liquor by using various chromatographic methods. Their structures were elucidated by spectrometric analysis. New compounds were characterized as 3-(3,3-dimethoxy-5α,7α-epidithio-17β-hydroxy-4-androstan-17α-yl) propionic acid γ-lactone (6); 3-(3-oxo-7α-acetylthio-6β,17β-dihydroxy-4-androsten-17α-yl) propionic acid γ-lactone (7); 7α-acetylthio-17β-20-isopropylidendioxy-21-nor-17α-pregn-4-en-3-one (8); 7α-acetylthio-3-oxo-pregna-4,17(20)i-dien-22-oic acid methyl ester (9) and 7α-acetylthio-17-methyl-18-nor-androsta-4-en-3-one (10).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 40, Issue 5, 18 March 2006, Pages 1263–1267
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 40, Issue 5, 18 March 2006, Pages 1263–1267
نویسندگان
Hua Chen, You-Fu Wang, Zhong-Duo Yang, Yuan-Chao Li,