کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1224529 1494677 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Isolation and identification of novel impurities in spironolactone
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Isolation and identification of novel impurities in spironolactone
چکیده انگلیسی

Three known and five new steroidal compounds as impurities in spironolactone were isolated from the enriched mother liquor by using various chromatographic methods. Their structures were elucidated by spectrometric analysis. New compounds were characterized as 3-(3,3-dimethoxy-5α,7α-epidithio-17β-hydroxy-4-androstan-17α-yl) propionic acid γ-lactone (6); 3-(3-oxo-7α-acetylthio-6β,17β-dihydroxy-4-androsten-17α-yl) propionic acid γ-lactone (7); 7α-acetylthio-17β-20-isopropylidendioxy-21-nor-17α-pregn-4-en-3-one (8); 7α-acetylthio-3-oxo-pregna-4,17(20)i-dien-22-oic acid methyl ester (9) and 7α-acetylthio-17-methyl-18-nor-androsta-4-en-3-one (10).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 40, Issue 5, 18 March 2006, Pages 1263–1267
نویسندگان
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