کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1224788 967932 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhancement of an analytical method for the determination of squalene in anthrax vaccine adsorbed formulations
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Enhancement of an analytical method for the determination of squalene in anthrax vaccine adsorbed formulations
چکیده انگلیسی
Specific lots of anthrax vaccine adsorbed administered to members of the U.S. Armed Forces have been alleged to contain squalene, a chemical purported to be associated with illnesses of Gulf War veterans. A method of enhanced sensitivity for determining squalene in anthrax vaccine adsorbed using high-performance liquid chromatography with photodiode array detection has been developed, validated, and applied to 44 bottles of 38 lots of anthrax vaccine. In 43 bottles of 37 lots, no squalene was detected within a detection limit of 1 ng/0.5 ml dose (2 parts-per-billion). One lot, FAV008, was found to contain trace amounts of squalene at 7, 9, and 1 μg l−1, levels considerably below normal human plasma levels (290 μg l−1). The overall results of this investigation provide direct evidence for the absence of squalene in nearly all of anthrax vaccine preparations tested.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 42, Issue 4, 11 October 2006, Pages 494-499
نویسندگان
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