کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1225485 1494788 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Actin carbonylation: From cell dysfunction to organism disorder
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Actin carbonylation: From cell dysfunction to organism disorder
چکیده انگلیسی


• Actin susceptibility to carbonylation
• Oxidised actin intracellular fate
• Involvement in cell dysfunction and organism disorders

Protein carbonylation is an important event in the context of proteostasis because of its frequency, non-enzymatic nature and irreversible effects. The carbonylation of proteins disturbs their function and leads to protein aggregates, which may precede cellular senescence and cell death.Actin, an evolutionarily conserved cytoskeletal protein that is involved in important cellular processes, is one of the proteins most susceptible to carbonylation. Conditions resulting in oxidative stress are likely to lead to its carbonylation, loss of function and aggregate formation. In this review, we summarise actin susceptibility to carbonylation, as verified in cell free extracts, cell lines and animal models, and review its fate through the activation of cell mechanisms aimed at removing damaged proteins. Their insufficient activity may underlie age-related diseases and the ageing process. This article is part of a Special Issue entitled: Posttranslational Protein modifications in biology and Medicine.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Proteomics - Volume 92, 30 October 2013, Pages 171–180
نویسندگان
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