3D-printed and CNC milled flow-cells for chemiluminescence detection

• Chemiluminescence flow-cells constructed by 3D-printing or machining.
• Aluminum flow-cell holder increases the transfer of light to the photodetector.
• A new spilt channel flow-cell with two detection zones was constructed and evaluated.

Herein we explore modern fabrication techniques for the development of chemiluminescence detection flow-cells with features not attainable using the traditional coiled tubing approach. This includes the first 3D-printed chemiluminescence flow-cells, and a milled flow-cell designed to split the analyte stream into two separate detection zones within the same polymer chip. The flow-cells are compared to conventional detection systems using flow injection analysis (FIA) and high performance liquid chromatography (HPLC), with the fast chemiluminescence reactions of an acidic potassium permanganate reagent with morphine and a series of adrenergic phenolic amines.

Figure optionsDownload as PowerPoint slide