کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1244840 969702 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Simultaneous chemiluminescence determination of promazine and fluphenazine using support vector regression
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Simultaneous chemiluminescence determination of promazine and fluphenazine using support vector regression
چکیده انگلیسی

In this work, chemiluminescence (CL) behaviors of two selected phenothiazines, namely promazine and fluphenazine hydrochloride, were investigated for their simultaneous determination using oxidation of Ru(bipy)32+ by Ce4+ ions in acidic media. This method is based on the kinetic distinction of the CL reactions of fluphenazine and promazine with Ru(bipy)32+ and Ce4+ system in a sulfuric acid medium. Least square support vector regression models were constructed for relating concentrations of both compounds to their CL profiles. The parameters of the model consisting of σ2 and γ were optimized using all possible combinations of σ2 and γ to select the model with the minimum root mean square cross validation. Under optimized conditions, the univariate calibration curve was linear over the concentration ranges of 0.4–30.0 μg mL−1 and 0.07–5.0 μg mL−1 with detection limits of 0.1 μg mL−1 and 0.04 μg mL−1 for promazine and fluphenazine, respectively. The influence of potential interfering substances on the determination of promazine and fluphenazine were studied. The proposed method was used for simultaneous determination of both compounds in synthetic mixtures and in spiked human plasma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Talanta - Volume 79, Issue 2, 15 July 2009, Pages 534–538
نویسندگان
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