کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1244861 | 969704 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Acidity of several polyprotic acids, amiodarone and quetiapine hemifumarate in pure methanol Acidity of several polyprotic acids, amiodarone and quetiapine hemifumarate in pure methanol](/preview/png/1244861.png)
Methanol is the organic solvent closest to water and able to dissolve a huge amount of organic compounds. Therefore, it is a good candidate for pKa determination of drugs sparingly soluble in water or a basic drug presented as a salt which pKa is close to that of its counter-acid. In this work, the acidic dissociation constants in pure methanol of the most common acids used in pharmaceutical preparations (lactic, tartaric, fumaric, maleic and citric) were determined. In addition, the pKa values of the antipsychotic quetiapine presented as hemifumarate (Seroquel) and the very insoluble antiarrhythmic amiodarone were also determined by potentiometry. From these values, the aqueous pKa of these drugs were estimated by means of previously established equations. Estimated values are consistent with those from literature and show the interest of methanol for drug discovery pKa measurements.
Journal: Talanta - Volume 73, Issue 1, 15 August 2007, Pages 115–120