کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1245049 | 969711 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Three optimized and validated (using accuracy profiles) LC methods for the determination of pentamidine and new analogs in rat plasma
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Three optimized and validated (using accuracy profiles) LC methods for the determination of pentamidine and new analogs in rat plasma Three optimized and validated (using accuracy profiles) LC methods for the determination of pentamidine and new analogs in rat plasma](/preview/png/1245049.png)
چکیده انگلیسی
By means of a recent strategy based on accuracy profiles (β-expectation tolerance interval), the methods were successfully validated. β was fixed at 95% and the acceptability limits at ±15% as recommended by the FDA. The method was successfully validated for PTMD (29.6-586.54 ng/mL), analog 1 (74.23-742.3 ng/mL) and analog 2 (178.12-890.6 ng/mL). The first concentration level tested was considered as the LLOQ (lower limit of quantification) for PTMD and analog 1 whereas for analog 2, the LLOQ was not the first level tested and was raised to 178.12 ng/mL.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Talanta - Volume 83, Issue 3, 15 January 2011, Pages 832-839
Journal: Talanta - Volume 83, Issue 3, 15 January 2011, Pages 832-839
نویسندگان
S. Hambÿe, D. Stanicki, J.-M. Colet, E.M. Aliouat, J.J. Vanden Eynde, B. Blankert,