کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1245551 969725 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimization of a FIA system with amperometric detection by means of a desirability function: Determination of sulfadiazine, sulfamethazine and sulfamerazine in milk
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Optimization of a FIA system with amperometric detection by means of a desirability function: Determination of sulfadiazine, sulfamethazine and sulfamerazine in milk
چکیده انگلیسی

A sensitive and cheap FIA, with amperometric detection, analytical procedure is developed in this paper to determine sulfadiazine, sulfamethazine and sulfamerazine in milk. A multicriteria optimization based on the use of a desirability function is used for optimizing two analytical responses (peak height and its variability) since single-objective optimizations lead to conflicting experimental conditions. In the optimum conditions, the determination of the three sulfonamides in milk samples is carried out, the analytical procedure being validated according to Commission Decision 2002/657/EC. The decision limit at 0 and 100 μg L−1 (which is the maximum residue limit in milk) are 13.9 and 110.2, 9.5 and 107.1 and 9.1 and 107.1 μg L−1 for sulfadiazine, sulfamethazine and sulfamerazine, respectively. Whereas the values of capability of detection, CCβ, obtained at 0 and 100 μg L−1 were 26.9 and 119.8, 18.2 and 113.6, and 17.5 and 113.7 μg L−1 for sulfadiazine, sulfamethazine and sulfamerazine, respectively. Recovery values between 67.4% and 119.1% are found for milk test samples of two brands of milk. The accuracy of the method is confirmed. The ruggedness of the procedure is evaluated by means of a Plackett–Burman design. The relative errors were lower than 2.5% (n = 7).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Talanta - Volume 75, Issue 1, 15 March 2008, Pages 274–283
نویسندگان
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