کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1245668 | 969729 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enantioselective, potentiometric membrane electrodes based on cyclodextrins: Application for the determination of R-baclofen in its pharmaceutical formulation
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Two enantioselective, potentiometric membrane electrodes based on α- and γ-cyclodextrins were proposed for the assay of R-baclofen. The slopes of the electrodes were 59.50 and 51.00 mV/pR-baclofen for α- and γ-cyclodextrin-based electrodes, respectively. The detection limits of the proposed electrodes were 7 × 10−9 mol l−1 for α-cyclodextrin-based electrode and 1.44 × 10−10 mol l−1 for γ-cyclodextrin-based electrode. The enantioselectivity was determined over S-baclofen. The proposed electrodes can be employed for the assay of R-baclofen raw materials and its pharmaceutical formulation, Norton-Baclofen® tablets. The surfaces of the electrodes are stable and easily renewable by polishing on alumina paper.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Talanta - Volume 69, Issue 5, 15 July 2006, Pages 1049–1053
Journal: Talanta - Volume 69, Issue 5, 15 July 2006, Pages 1049–1053
نویسندگان
Raluca-Ioana Stefan van Staden, Alexander A. Rat’ko,