کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1247996 | 1495922 | 2013 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Aqueous normal-phase chromatography using silica-hydride-based stationary phases Aqueous normal-phase chromatography using silica-hydride-based stationary phases](/preview/png/1247996.png)
Aqueous normal-phase chromatography utilizing silica-hydride-based stationary phases provides unique selectivities for the separation of polar and non-polar compounds and offers new avenues to solve difficult analytical separations. By varying the amount of water in the mobile phase, all silica-hydride-based separation materials can operate in the reversed-phase mode, the normal-phase mode or, in some instances, a combination of both.This review describes some of the fundamental properties of silica-hydride materials and applications that encompass a broad range of separation challenges. Moreover, exemplars are provided that illustrate many of the prominent features that lead to the selection of such stationary phases for solving a particular analytical problem.
► The unique separation properties of silica-hydride materials are described.
► Silica-hydride materials can retain both polar and non-polar compounds.
► Applications to pharmaceuticals, peptides and polar metabolites are presented.
Journal: TrAC Trends in Analytical Chemistry - Volume 42, January 2013, Pages 64–73