Advances in H2 sensors for bioanalytical applications

• H2 detection techniques are essential for H2 medicine.
• H2 sensors can monitor biodegradation of Mg alloys being developed for repair of broken bones.
• Electrochemical methods for H2 detection have attracted more attention in bioanalytical applications.
• Optical sensors for H2 detection in bioanalysis are simple, effective and visual.
• Color indicator sensors for H2 detection have been used for screening hydrogen-producing microorganisms.

H2 sensors have been receiving more attention, especially with the development of H2 medicine and biodegradable alloys that produce H2. The H2 sensors discussed in this review are primarily the electrochemical, chemochromic metal oxide, and color indicator sensors. This review focuses on the bioanalytical application of these existing H2 sensors. The performance parameters of these sensors are reviewed to aid in identifying and selecting appropriate sensors for practical applications.