Development of electrochemical DNA biosensors

Due to the rapid response, the high sensitivity, the good selectivity and the experimental convenience of the electrochemical DNA biosensor, its applications have attracted broad interest.This article reviews electrochemical DNA biosensors and different methods proposed for their construction to overcome their limitations in selectivity and sensitivity. We also discuss their performance and future prospects.

► Electrochemical DNA biosensors offer many advantages for DNA-sequence detection.
► We reviewed the development of electrochemical DNA biosensors.
► Immobilization and configuration were important factors influencing performance.
► We showed how electrochemical transductions produce sensitive assays.