Keywords: اسید نوکلئیک قفل شده; Nanobiosensor; Gapmer; Aptamer; Locked nucleic acid; Gene expression;
مقالات ISI اسید نوکلئیک قفل شده (ترجمه نشده)
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Keywords: اسید نوکلئیک قفل شده; Locked nucleic acid; Molecular beacons; Loop mediated isothermal amplification; Multiplex detection;
Keywords: اسید نوکلئیک قفل شده; AAC; abdominal aortic constriction; ADAMS; a disintegrin and metalloproteases; ADAMTS; a distingetrin and metalloproteinase with a thrombospondin domain; Ang II; angiotensin II; BM; basement membrane; BMP-1; bone morphogenic protein-1; CITP; carboxy-termi
Keywords: اسید نوکلئیک قفل شده; Asthma; COPD; DNA methylation; Fibrosis; Histone code; Noncoding RNA; ACD/MPV; alveolar capillary dysplasia and misalignment of pulmonary veins; BMPR2; bone morphogenetic protein receptor 2; COPD; chronic obstructive pulmonary disease; COX-2; cyclooxygena
Keywords: اسید نوکلئیک قفل شده; ALAS1; δ-aminolevulinate synthase 1; ANGPTL3; angiopoietin-like 3; FVII; factor VII; FXI; factor XI; GCGR; glucagon receptor; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; HoFH; homozygous familial hypercholesterolemia; KSP; kinesin spindle prot
MMISH: Multicolor microRNA in situ hybridization for paraffin embedded samples
Keywords: اسید نوکلئیک قفل شده; TnI; Troponin I; LNA; locked nucleic acid; NBT/BCIP; combination of nitro-blue tetrazolium chloride and 5-bromo-4-chloro-3â²-indolyphosphate p-toluidine salt; EDC; 1-Ethyl-3-[3-dimethylaminopropyl] carbodimide hydrochloride; MI; myocardial infarction; Tm
Large-scale screening of circulating microRNAs in individuals with HIV-1 mono-infections reveals specific liver damage signatures
Keywords: اسید نوکلئیک قفل شده; HIV-1 infection; Circulating microRNAs; Liver disease; HIV-1; Human immunodeficiency virus type 1; miRNA; microRNA; ALT; alanine aminotransferase; FNH; focal nodular hyperplasia; HCV; Hepatitis C virus; AST; aspartate aminotransferase; HCC; hepatocellular
Locked nucleic acid -anti- let-7a induces apoptosis and necrosis in macrophages infected with Leishmania major
Keywords: اسید نوکلئیک قفل شده; MicroRNA; miRNA; let-7a; Locked nucleic acid; Leishmaniasis;
Long Noncoding RNA uc.173 Promotes Renewal of the Intestinal Mucosa by Inducing Degradation of MicroRNA 195
Keywords: اسید نوکلئیک قفل شده; lncRNAs; IEC; Post-transcriptional Regulation; Mouse Model; BrdU; bromodeoxyuridine; DFMO; D,L-α-difluoro-methylornithine; FISH; fluorescence in situ hybridization; IEC; intestinal epithelial cell; LNA; locked nucleic acid; lncRNA; long noncoding RNAs; L
Interactions between microRNAs and long non-coding RNAs in cardiac development and repair
Keywords: اسید نوکلئیک قفل شده; AAV; adeno-associated virus; AMI; acute myocardial infarction; APF; autophagy promoting factor; Bvht; Braveheart; CARL/Carl; cardiac apoptosis-related lncRNA; CARMEN/Carmen; cardiac mesoderm enhancer-associated non-coding RNA; CHAER/Chaer; cardiac-hypertr
A ratiometric electrochemical biosensor for the exosomal microRNAs detection based on bipedal DNA walkers propelled by locked nucleic acid modified toehold mediate strand displacement reaction
Keywords: اسید نوکلئیک قفل شده; Ratiometric electrochemical biosensor; Exosomal miRNAs; Bipedal DNA walker; Locked nucleic acid; Toehold mediate strand displacement reaction;
A sense oligonucleotide to inducible nitric oxide synthase mRNA increases the survival rate of rats in septic shock
Keywords: اسید نوکلئیک قفل شده; Sense oligonucleotide; Non-coding RNA; Sepsis; Endotoxemia; Liver failure; NATRE technology; LPS; lipopolysaccharide; NO; nitric oxide; iNOS; inducible nitric oxide synthase; IL; interleukin; TNF-α; tumor necrosis factor α; asRNA; antisense transcripts;
Short communicationAn in vitro model of catheter-associated urinary tract infections to investigate the role of uncommon bacteria on the Escherichia coli microbial consortium
Keywords: اسید نوکلئیک قفل شده; EPS; extracellular polymeric substance; FISH; fluorescence in situ hybridization; CLSM; confocal laser scanning microscopy; LNA; locked nucleic acid; 2â²OMe; 2â²-O-Methyl-RNA; CAUTIs; catheter-associated urinary tract infections; TSA; tryptic soy agar;
A universal locked nucleic acid-integrated X-shaped DNA probe design for amplified fluorescence detection of single-nucleotide variant
Keywords: اسید نوکلئیک قفل شده; Single-nucleotide variant; X-shaped DNA probe; Locked nucleic acid; Toehold-mediated strand-displacement reaction; β-thalassemia; Fluorescence detection;
EGFR mutation prevalence in Asia-Pacific and Russian patients with advanced NSCLC of adenocarcinoma and non-adenocarcinoma histology: The IGNITE study
Keywords: اسید نوکلئیک قفل شده; ADC; adenocarcinoma; aNSCLC; advanced non-small-cell lung cancer; ASR; age-standardised rate; ctDNA; circulating free tumour-derived DNA; EGFR; epidermal growth factor receptor; LNA; locked nucleic acid; NE; neuroendocrine; NSCC; non-small-cell carcinoma;
Functional integration of complex miRNA networks in central and peripheral lesion and axonal regeneration
Keywords: اسید نوکلئیک قفل شده; AAV(s); adeno-associated virus(es); ADAM; a disintegrin and metalloprotease; AGO(2); argonaut (2); AKT; protein kinase B; APC; adenomatous polyposis coli; ASO(s); antisense oligonucleotide(s); ATF3; activating transcription factor 3; BBB; blood brain barr
Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells
Keywords: اسید نوکلئیک قفل شده; miRNA; microRNA; NT2; testicular embryonal carcinoma cell; IRF2; interferon regulatory transcription factor 2; 3â² UTR; 3â²-untranslated region; NC; negative control; siRNA; small interfering RNA; ISH; in situ hybridization; LNA; locked nucleic acid; DM
Hybridization chain reaction directed DNA superstructures assembly for biosensing applications
Keywords: اسید نوکلئیک قفل شده; Hybridization chain reaction; Isothermal amplification; Nanotechnology; Biosensor; Ultrahigh sensitivity; AFP; alpha-fetoprotein; AgNPs; silver nanoparticles; ATP; adenosine triphosphate; AuNPs; gold nanoparticles; cDNA; complementary DNA; CEA; carcinoemb
MicroRNAs as Important Regulators of Exercise Adaptation
Keywords: اسید نوکلئیک قفل شده; AUC; Area under the curve; CAD; Coronary artery disease; CRF; Cardiorespiratory fitness; CV; Cardiovascular; CVD; Cardiovascular disease; ET; Exercise training; HF; Heart failure; hsa; Homo sapiens (human); HUNT; The Nord-Trøndelag Health Study; HF; Hear
Prospective validation of a blood-based 9-miRNA profile for early detection of breast cancer in a cohort of women examined by clinical mammography
Keywords: اسید نوکلئیک قفل شده; Breast cancer; Serum; Circulating miRNA profile; Biomarker; Early detection; ER; estrogen receptor; HER2; human epidermal growth factor 2; miRNA; microRNA; SOP; standard operational procedures; LNA; locked nucleic acid; AUC; area under the curve; ROC; rec
A new real-time RT-qPCR assay for the detection, subtyping and quantification of human respiratory syncytial viruses positive- and negative-sense RNAs
Keywords: اسید نوکلئیک قفل شده; 6-FAM; 6-carboxyfluorescein; BHQ; black hole quencher; CT; threshold cycle; hMPV; human metapneumovirus; hPIV; human parainfluenza virus; L-LOD; lower limit of detection; LNA; locked nucleic acid; MGB-NFQ; minor-groove binder non-fluorescence quencher; QC
Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides
Keywords: اسید نوکلئیک قفل شده; Antisense oligonucleotides; GalNAc; Asialoglycoprotein receptors; Bio-labile linker; Bridged nucleic acid; Locked nucleic acid; Apolipoproteins; Hypercholesterolemia
MicroRNAs regulate mitochondrial apoptotic pathway in myocardial ischemia-reperfusion-injury
Keywords: اسید نوکلئیک قفل شده; MiRNA; microRNAs; I/R; ischemia/reperfusion; O2â; superoxide anions; ROS; reactive oxygen species; MI; myocardial infarction; I/RI; ischemia/reperfusion injury; PKCε; protein kinase Cε; H/R; hypoxia/reperfusion; LNA; locked nucleic acid; PDCD4; progra
miR-181b-3p promotes epithelial-mesenchymal transition in breast cancer cells through Snail stabilization by directly targeting YWHAG
Keywords: اسید نوکلئیک قفل شده; AP; alkaline phosphatase; DIG; digoxigenin; CHX; cycloheximide; EGF; epidermal growth factor; EMT; epithelial-mesenchymal transition; FBS; fetal bovine serum; FGF; fibroblast growth factor; GSK3β; glycogen synthase kinase 3β; IHC; immunohistochemistry
Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction
Keywords: اسید نوکلئیک قفل شده; aging; autophagy; circulating miRNA; MiR-22; p62; Atg; autophagy-related gene; FACS; fluorescence-activated cell sorting; GFP; green fluorescent protein; LNA; locked nucleic acid; MI; myocardial infarction;
Direct detection of circulating free DNA extracted from serum samples of breast cancer using locked nucleic acid molecular beacon
Keywords: اسید نوکلئیک قفل شده; cfDNA; circulating free DNA; PCR; polymerase chain reaction; UHRF1; Ubiquitin-like with PHD and ring finger domains 1; BC; breast cancer; LNA-MB; locked nucleic acid modified molecular beacon; PNA; peptide nucleic acid; NCBI; National Center for Biotechno
Research ArticleComplete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model
Keywords: اسید نوکلئیک قفل شده; HCC; hepatocellular cancer; LNA; locked nucleic acid; DEN/PB; diethylnitrosamine and phenobarbital; GSK-3β; glycogen synthase kinase-3β; APC; Adenomatous polyposis coli; Fzd; Frizzled; LRP; low-density lipoprotein receptor related protein; CREB; cAMP re
RNA therapeutics inactivate PCSK9 by inducing a unique intracellular retention form
Keywords: اسید نوکلئیک قفل شده; CTR; control; CRISPR; clustered regularly interspaced short palindromic repeats; EDTA; ethylenediaminetetraacetic acid; FBS; fetal bovine serum; HPRT; hypoxanthine-guanine phosphoribosyltransferase; LDL-C; low-density lipoprotein cholesterol; LDLR; low-de
MicroRNAs in osteosarcoma
Keywords: اسید نوکلئیک قفل شده; OS; osteosarcoma; miRNAs; microRNAs; CSCs; cancer stem cells; RNA pol; RNA polymerase; DGCR8; DiGeorge syndrome critical gene 8; RISC; RNA-induced silencing complex; Exp 5; exportin 5; Ago; argonaute; MREs; miRNA recognition elements; APE1; apurinic/apyri
scaRNAs regulate splicing and vertebrate heart development
Keywords: اسید نوکلئیک قفل شده; AS; alternative splicing; CHDs; congenital heart defects; RV; right ventricle; TOF; tetralogy of Fallot; scaRNAs; small cajal body-specific RNAs; CHD; congenital heart disease; SHF; second heart field; ncRNA; noncoding RNA; snRNAs; small nuclear RNAs; sno
Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice
Keywords: اسید نوکلئیک قفل شده; miR; microRNA; BACE1; beta secreatase; AD; Alzheimer's disease; NAV3; neuronal navigator 3; SCA17; spinocerebellar ataxia 17; FISH; fluorescence in situ hybridization; LNA; locked nucleic acid; APP; amyloid precursor protein; PMP22; peripheral myelin prot
Targeting strategies on miRNA-21 and PDCD4 for glioblastoma
Keywords: اسید نوکلئیک قفل شده; GBM; glioblastoma multiforme; miRNAs; microRNAs; PDCD4; programmed cell death 4; EMT; epithelial-mesenchymal transition; JNK; Jun N-terminal protein kinase; PTEN; phosphatase and tensin homolog; PI3K/AKT; phosphatidylinositol-3 kinase/Akt; MAPK/ERK; mit
Developments in in situ hybridisation
Keywords: اسید نوکلئیک قفل شده; In situ hybridisation; Signal amplification; Tissue fixation; Locked nucleic acid; Rolling circle amplification; Branched DNA amplification;
Locked nucleic acid/DNA chimeric aptamer probe for tumor diagnosis with improved serum stability and extended imaging window in vivo
Keywords: اسید نوکلئیک قفل شده; AAP, activatable aptamer probe; LNA, locked nucleic acid; 3′-3′-T, 3′-3′-thymidine; t1/2, half-life; FBS, fetal bovine serum; % Gated, the percentage of labeled events appearing in the Gate M1Aptamer; Imaging agent; In vivo; Locked nucleic acid; Nuclease-
The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy
Keywords: اسید نوکلئیک قفل شده; cDNA; complementary DNA; DAPI; 4â²,6-diamidino-2-phenylindole; db/db; BKS.Cg-m+/+Leprdb/J; db/m; heterozygote mice; DIG; digoxin; DRG; dorsal root ganglion; HG; high glucose; IRAK1; interleukin-1 receptor-activated kinase; LNA; locked nucleic acid; MCID;
Small RNA expression and deep sequencing analyses of the nucleolus reveal the presence of nucleolus-associated microRNAs
Keywords: اسید نوکلئیک قفل شده; ActD; Actinomycin D; CRM1; chromosomal maintenance 1; LNA; locked nucleic acid; pre; precursor; qPCR; quantitative real-time PCR; Pol I; RNA polymerase I; rRNA; ribosomal RNA; siRNA; short interfering RNA; snoRNA; small nucleolar RNA; Small RNA; Nucleolus
Ionizing radiation-inducible miR-494 promotes glioma cell invasion through EGFR stabilization by targeting p190B RhoGAP
Keywords: اسید نوکلئیک قفل شده; ECM; extracellular matrix; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor (EGFR); FACS; fluorescence-activated cell sorting; FBS; fetal bovine serum; GAP; GTPase activating protein; GEF; guanine nucleotide exchange factor; IR; ionizi
Sfmbt2 10th intron-hosted miR-466(a/e)-3p are important epigenetic regulators of Nfat5 signaling, osmoregulation and urine concentration in mice
Keywords: اسید نوکلئیک قفل شده; 3â²UTR; 3â²-untranslated region; AVP; arginine vasopressin; Aqp1/2/3; aquaporin-1/2/3; Ar; aldose reductase; Cdkn1c or p57; Cyclin-dependent kinase inhibitor 1C; C2MC; Chromosome 2 miRNA cluster; Dcx; Doublecortin; ddAVP; 1-desamino-8-d-arginine vasopre
Aldose reductase regulates miR-200a-3p/141-3p to coordinate Keap1-Nrf2, Tgfβ1/2, and Zeb1/2 signaling in renal mesangial cells and the renal cortex of diabetic mice
Keywords: اسید نوکلئیک قفل شده; 3â²UTR; 3â²-untranslated region; ACVR2B; activin receptor type 2B; AR/Ar; aldose reductase; ARI; aldose reductase inhibitor; BT; KspAr+/â::Arâ/â bitransgenics; Col4; collagen IV; DN; diabetic nephropathy; E-cad; E-cadherin; ECM; extracellular matr
Distinct functions of alternatively spliced isoforms encoded by zebrafish mef2ca and mef2cb
Keywords: اسید نوکلئیک قفل شده; AS; Alternative Splicing; MEF2; Myocyte Enhancer Factor 2; BMP; Bone Morphogenetic Protein; MADS; Minichromosome maintenance, Agamous, Deficiens, Serum response factor; TAD; transcription activating domains; PKA; Protein Kinase A; qRTPCR; quantitative Rea
Successful use of saliva without DNA extraction for detection of macrolide-resistant Mycoplasma pneumoniae DNA in children using LNA probe-based real-time PCR
Keywords: اسید نوکلئیک قفل شده; Direct real-time PCR; Locked nucleic acid; Macrolide-resistant; Mycoplasma pneumoniae; Rapid diagnosis;
Simultaneous detection, typing and quantitation of oncogenic human papillomavirus by multiplex consensus real-time PCR
Keywords: اسید نوکلئیک قفل شده; HPV; human papillomavirus; GU; genomic units; LNA; locked nucleic acid; MGB; minor groove binder; HC2; hybrid capture test; HPV; High-risk HPV; Real-time PCR; Cervical cancer; Cervical screening;
Silencing of miR-21 by locked nucleic acid-lipid nanocapsule complexes sensitize human glioblastoma cells to radiation-induced cell death
Keywords: اسید نوکلئیک قفل شده; Glioblastoma; MicroRNA; Locked nucleic acid; Lipid nanocapsules; Radiotherapy;
Progress in microRNA delivery
Keywords: اسید نوکلئیک قفل شده; AMO; anti-miRNA oligonucleotides; APP; amyloid precursor protein; BBB; blood-brain barrier; bp; base pairs; CNS; central nervous system; CSC; cancer stem cell; DDAB; dimethyldioctadecylammonium bromide; DGCR8; DiGeorge syndrome critical region gene; DNA
An electrochemical nanobiosensor for plasma miRNA-155, based on graphene oxide and gold nanorod, for early detection of breast cancer
Keywords: اسید نوکلئیک قفل شده; TMB; 3,3â²,5,5â²-tetramethylbenzidine; LNA; locked nucleic acid; HRP; Horseradish peroxidase; MB; methylene blue; AP; alkaline phosphatase; HQ; hydroquinone; BQ; benzoquinone; AuNP; Gold NP; GNR; gold nanorod; GO; graphene oxide; MWCNTs; multi-walled ca
Enzymatic polymerisation involving 2′-amino-LNA nucleotides
Keywords: اسید نوکلئیک قفل شده; 2′-Amino-LNA; Locked nucleic acid; Modified nucleosides; Primer extension; Triphosphate
Fabrication of DNA electrochemical biosensor based on gold nanoparticles, locked nucleic acid modified hairpin DNA and enzymatic signal amplification
Keywords: اسید نوکلئیک قفل شده; DNA biosensor; Gold nanoparticles; Hairpin DNA; Locked nucleic acid; Hybridization
Electrochemical determination of microRNA-21 based on graphene, LNA integrated molecular beacon, AuNPs and biotin multifunctional bio bar codes and enzymatic assay system
Keywords: اسید نوکلئیک قفل شده; MicroRNA-21; Graphene; Dendritic gold nanoparticles; Locked nucleic acid; Hairpin molecule beacon; Electrochemical biosensor;
Development of electrochemical DNA biosensors
Keywords: اسید نوکلئیک قفل شده; DNA detection; Electrochemical DNA biosensor; Enzyme-amplified electrochemical DNA assay; Hairpin DNA; Hybridization; Locked nucleic acid; Mediator; Nanomaterial; Nucleic-acid biosensor; Peptide nucleic acid
Micro-RNA-34a Contributes to the Impaired Function of Bone Marrow-Derived Mononuclear Cells From Patients With Cardiovascular Disease
Keywords: اسید نوکلئیک قفل شده; acute myocardial infarction; bone marrow mononuclear cells; cell therapy; locked nucleic acid; microRNA; miR-34aAMI, acute myocardial infarction; ANOVA, analysis of variance; BMC, bone marrow–derived mononuclear cell; CDK, cyclin-dependent kinases; DCM, d