کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5553329 | 1557958 | 2016 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: MicroRNAs regulate mitochondrial apoptotic pathway in myocardial ischemia-reperfusion-injury MicroRNAs regulate mitochondrial apoptotic pathway in myocardial ischemia-reperfusion-injury](/preview/png/5553329.png)
MicroRNAs (miRNAs) are small non-coding RNAs that act as post-transcriptional gene regulators. They are involved in the pathogenesis of different disorders including heart diseases. MiRNAs contribute to ischemia/reperfusion injury (I/RI) by altering numerous key signaling elements. Together with alterations in the various potential signaling pathways, modification in miRNA expression has been suggested as a part of the response network following ischemia/reperfusion (I/R). In addition, cardiac mitochondrial homeostasis is closely associated with cardiac function and impairment of mitochondrial activity occurred after ischemia/reperfusion injury. MiRNAs play a key role in the regulation of mitochondrial apoptotic pathway and signaling proteins. In this review, we summarize the knowledge currently available regarding the molecular mechanisms of miRNA-regulated mitochondrial functions during ischemia/reperfusion injury. This regulation occurs in different stages of mitochondrial apoptosis pathway.
Journal: Biomedicine & Pharmacotherapy - Volume 84, December 2016, Pages 1635-1644