کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1248907 | 970473 | 2006 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Metallodrug research and analysis using capillary electrophoresis Metallodrug research and analysis using capillary electrophoresis](/preview/png/1248907.png)
We review current and emerging capabilities of capillary electrophoresis (CE) as employed for metallodrug development. The application of gentle separation schemes and successful combinations with element-specific and molecule-specific mass-spectrometric detectors have increased the importance of CE as a tool in this area of biochemical speciation analysis.This article highlights recent progress of the method in assessing drug stability, separating metallodrugs and their metabolites, characterizing related metal-bioligand species, describing the kinetics and equilibrium of the corresponding metabolic processes, and analyzing biofluids.Finally, we discuss strategies for developing CE methods in metabolomic and proteomic analysis, centered on metal-based drugs so as ultimately to facilitate their discovery and preclinical investigation.
Journal: TrAC Trends in Analytical Chemistry - Volume 25, Issue 9, October 2006, Pages 868–875