کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1249101 | 1495902 | 2014 | 13 صفحه PDF | دانلود رایگان |
• Infrared (IR) spectroscopy techniques for clinical analysis and diagnostics.
• IR analysis of solid, liquid and gaseous clinical samples.
• Developments in IR spectroscopy based on sample and chemometric data treatments.
• Direct analysis using IR spectroscopy without chromatographic separations.
Infrared (IR) spectroscopy has become a promising technique for the analysis of clinical samples, and IR-based diagnosis is already a well-established technique in the academic field. This review aims to report the methodologies proposed for IR quantification of different analytes and parameters in a variety of clinical samples; including: liquids, such as whole blood, serum, plasma, urine, human milk, amniotic fluid and cerebrospinal fluid; solids, such as urinary stones, skin, hair and lips; breath; or, microscopic quantifications on tissues. For the application of IR spectroscopy to the clinical field, we also discuss: the benefits, which make IR spectroscopy ideally suited to modern medicine; and, the limitations, which are connected with sensitivity and selectivity issues. The review focuses on recent developments based on modern improvements on chemometric algorithms, sample treatment and direct measurements on samples.
Journal: TrAC Trends in Analytical Chemistry - Volume 62, November 2014, Pages 93–105