کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1249431 970662 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CE-ICP-MS for studying interactions between metals and biomolecules
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
CE-ICP-MS for studying interactions between metals and biomolecules
چکیده انگلیسی

Metal-biomolecule interactions comprise an important research area in metallomics, and are significant for biology, medicine, pharmacy, nutrition, metabolism, and environmental science. Hybrid techniques are preferred for studying interactions between metals and biomolecules. Of all the separation techniques, capillary electrophoresis (CE) exhibits high resolution, minimal sample and reagent consumption, and rapid and efficient separations with minor disturbance of the existing equilibrium between the metal species and their biomolecular complexes. Inductively coupled plasma mass spectrometry (ICP-MS) presents high sensitivity to most of elements and offers multi-element detection.This article provides an overview of CE-ICP-MS for the study of metal-biomolecule interactions. We discuss applications of CE-ICP-MS to the study of interactions between metals or metalloids and natural ligands, such as humic substances or fulvic acids, and the interchange of metal complexes with metal species in metalloproteins.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: TrAC Trends in Analytical Chemistry - Volume 27, Issue 6, June 2008, Pages 554–565
نویسندگان
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