کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1299252 1498784 2011 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recent advances in understanding blue copper proteins
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Recent advances in understanding blue copper proteins
چکیده انگلیسی

The type 1 (T1) or blue Cu (BC) proteins are a highly studied group of electron transfer (ET) active sites in bioinorganic chemistry. In this review, we cover several more recent results which extend the understanding of the geometric and electronic structure of these interesting Cu ET sites. Spectroscopic methods in tandem with density functional theory (DFT) and time dependent-DFT (TD-DFT) calculations have been used in studies of S → Se variants as well as a series of metal-varied model complexes (M = Mn2+ → Zn2+). The ligand and metal perturbations further defined the origins of the unique spectral features of BC proteins. These unique spectral features show different temperature dependencies in different T1 sites, and contrasts drawn between their behaviors define the role of the protein in tuning the geometric and electronic structure of the BC site for function. This has been termed the ‘entatic’ or ‘rack-induced’ state in bioinorganic chemistry.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Coordination Chemistry Reviews - Volume 255, Issues 7–8, April 2011, Pages 774–789
نویسندگان
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