Chiral polyoxometalate-based materials: From design syntheses to functional applications

► We review the synthesis strategies and recent results of chiral polyoxometalates (POMs). ► Theoretical calculations on the origin of chirality within chiral POMs were discussed. ► The applications of chiral POMs in asymmetric catalysis, molecular recognition and NLO materials were summarized. ► The challenges of preparation and applications of chiral POMs were discussed.