کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1300797 | 1498710 | 2016 | 32 صفحه PDF | دانلود رایگان |
• Listing of 26 highly tumour active palladium compounds along with their structures.
• Possible palladium drug candidates for clinical trial.
• Characteristics of ligands and complexes influencing antitumour activity.
This article provides a comprehensive review of palladium compounds that have been evaluated for anticancer activity in vivo or in vitro from the era of discovery of cisplatin up to 2015. In total, 847 compounds have been discussed into three categories namely (1) potent palladium compounds, (2) palladium compounds with comparable activity and (3) palladium compounds with insignificant activity. Structure activity relationships are proposed that may aid in the design of new palladium compounds with greater antitumour activity.
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Journal: Coordination Chemistry Reviews - Volume 316, 1 June 2016, Pages 36–67