کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1301072 | 1498769 | 2012 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Photochemically activated carbon monoxide release for biological targets. Toward developing air-stable photoCORMs labilized by visible light Photochemically activated carbon monoxide release for biological targets. Toward developing air-stable photoCORMs labilized by visible light](/preview/png/1301072.png)
The potential therapeutic effects of carbon monoxide in several disease states, and new methodologies for CO delivery to specific targets is a topic of growing interest in mammalian physiology. Here we provide an overview of recent efforts in this laboratory regarding several types of carbonyl complexes of the group 6 metal and of those in other laboratories that are focused on developing photochemical techniques for such CO delivery. Photo-activated carbon monoxide releasing moieties (photoCORMs) based on manganese, iron and group 6 metals are described.
► We describe desired properties for photochemical CO delivery to biological targets.
► We also describe analytical challenges encountered in developing photoCORMs.
► We outline previous investigations of photoCORMs published by us and others.
► We present a new class of photoCORMs where CO is labilized by visible light.
Journal: Coordination Chemistry Reviews - Volume 256, Issues 15–16, August 2012, Pages 1509–1519