کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1301547 1498840 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Uranium(VI) bio-coordination chemistry from biochemical, solution and protein structural data
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Uranium(VI) bio-coordination chemistry from biochemical, solution and protein structural data
چکیده انگلیسی

The biocoordination chemistry of the uranyl cation (uranium(VI), [UO2]2+) is assessed utilizing data from the Protein Databank, solution thermodynamic data and biochemical experiments. Uranyl cation is effectively transported in the bloodstream through interactions with carbonate and protein ligands. Under physiologic conditions, carboxylate donors from biological ligands to uranyl are expected to compete favorably against carbonate in the inner sphere of the tris-carbonato uranyl complex. Carboxylate donors from aspartate, glutamate or the carboxyl terminus in proteins make up the majority of inner-sphere interactions with uranyl in protein structures that include this cation. Other significant interactions include amide oxygen donors in the inner-sphere, and H-bonding to uranyl oxo ligands by amide NH donors. These inner- and outer-sphere interactions are also present in structures of uranyl–amino acid complexes, and in other uranyl complexes with small molecules. In the solution state, uranyl–carboxylate interactions have been measured with thermodynamic values for stepwise conditional formation constants on the order of log K ≈ 2–5, similar to uranyl–acetate interactions. In addition to inner-sphere coordination, H-bonding and charge effects, as well as local chemical environmental conditions, play significant roles in the outer sphere; these interactions are somewhat less characterized in the literature.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Coordination Chemistry Reviews - Volume 250, Issues 7–8, April 2006, Pages 765–775
نویسندگان
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