Phosphorus-nitrogen compounds: Part 31. Syntheses, structural and stereogenic properties, in vitro cytotoxic and antimicrobial activities, and DNA interactions of bicyclotetraphosphazenes containing bulky side group

N4P4Cl8 was reacted with aminopodand to obtain 2,6-sas-phosphazene. The mono- and diamino-2,6-sas phosphazenes were prepared, and their characterizations were made. The interactions between the phosphazenes and pBR322 plasmid DNA, the evaluations for cytotoxic activity, and apoptotic and necrotic effects against A549 lung cancer and L929 fibroblast cell lines were studied.