کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1312109 | 1499162 | 2015 | 8 صفحه PDF | دانلود رایگان |
• Vanadocene complexes bearing substituted 2,2′-bipyridines and 4,5-diazafluoren-9-one were prepared.
• Spectroscopic and X-ray crystallographic data are presented.
• Cytotoxicity toward leukemia cells MOLT-4 and HL-60 was established.
This study describes the synthesis of vanadocene compounds [Cp′2V(L)][OTf]2, where Cp′ is substituted cyclopentadienyl ring and L is N,N-chelating ligand. All prepared compounds were characterized by analytical and spectroscopic methods. The structures of [(η5-C5H4Me)2V(bpy)][OTf]2, [(η5-C5H4iPr)2V(bpy)][OTf]2·CH2Cl2, [Cp2V(4,4′-Me2-bpy)][OTf]2, [Cp2V{4,4′-(MeO)2-bpy}][OTf]2·MeOH and [(η5-C5H4Me)2V(dafone)][OTf]2 were further confirmed by the X-ray diffraction analysis. The cytotoxicity study, performed on human leukemia cells MOLT-4 and HL-60, demonstrates that the activity of the vanadocene complexes strongly depends on the nature of the coordinated chelating ligand. The high cytotoxicity was observed for the complex bearing 2,2′-bipyridine, [(η5-C5H4Me)2V(bpy)][OTf]2, that shows IC50 values close to the data observed for cisplatin.
Series of vanadocene compounds [Cp′2V(L)][OTf]2, where Cp′ is substituted cyclopentadienyl ring and L is N,N-chelating ligand, was synthesized and characterized. The cytotoxicity study was performed on human leukemia cells MOLT-4 and HL-60. The high cytotoxicity was observed for the complex bearing 2,2′-bipyridine, [(η5-C5H4Me)2V(bpy)][OTf]2, that shows IC50 values close to the data observed for cisplatin.Figure optionsDownload as PowerPoint slide
Journal: Inorganica Chimica Acta - Volume 427, 1 March 2015, Pages 211–218