کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1316500 976464 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytotoxicity of mesoporous silica nanomaterials
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Cytotoxicity of mesoporous silica nanomaterials
چکیده انگلیسی

We here measure the toxicity of MCM-41, a mesoporous silica nanomaterial, two of its functionalized analogs, AP-T, which has grafted aminopropyl groups and MP-T, which has grafted mercaptopropyl groups, and spherical silica nanoparticles (SiO2), toward human neuroblastoma (SK–N–SH) cells. Since the particles studied are not soluble in aqueous media, the metric used to report the cytotoxicity of these materials is a new quantity, Q50, which is the number of particles required to inhibit normal cell growth by 50%. Determining the number of particles per gram of material applied to the cells required both the calculated and experimentally determined surface areas of these nanomaterials. This study shows that Q50 increases in the order, MCM-41 < MP-T < AP-T ≈ SiO2, showing that on a per particle basis, MCM-41 is the most cytotoxic material studied. For the three mesoporous silica materials in this study, cytotoxicity appears related to the adsorptive surface area of the particle, although the nature of the functional group cannot be ruled out. Silica nanospheres have the lowest surface area of the particles studied but since they exhibit a Q50 value similar to that of AP-T, shape may also be important in the cytotoxicity of these materials.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 102, Issue 7, July 2008, Pages 1416–1423
نویسندگان
, , , , , , ,