کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1316914 | 976491 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Combinatorial discovery of new asymmetric cis platinum anticancer complexes is made possible with solid-phase synthetic methods
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
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چکیده انگلیسی
To efficiently access asymmetric cis platinum (II) complexes for biological evaluation, a new solid-phase synthesis was designed. This synthesis was used for the preparation of a small library of platinum compounds. Several compounds from this library revealed promising activity during a cytotoxicity screen. Two active compounds were, therefore, synthesised on a larger scale and tested more extensively against a larger panel of cell-lines, confirming their high potential as antitumour compounds. The work presented illustrates how a combination of a new methodology and established techniques can speed up the search for platinum complexes with improved cytotoxic profiles compared to cisplatin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 99, Issue 10, October 2005, Pages 2032–2038
Journal: Journal of Inorganic Biochemistry - Volume 99, Issue 10, October 2005, Pages 2032–2038
نویسندگان
Steven van Zutphen, Elizabeth A. Stone, Sabine van Rijt, Marc S. Robillard, Gijs A. van der Marel, Herman S. Overkleeft, Hans den Dulk, Jaap Brouwer, Jan Reedijk,