کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1316914 976491 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Combinatorial discovery of new asymmetric cis platinum anticancer complexes is made possible with solid-phase synthetic methods
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Combinatorial discovery of new asymmetric cis platinum anticancer complexes is made possible with solid-phase synthetic methods
چکیده انگلیسی

To efficiently access asymmetric cis platinum (II) complexes for biological evaluation, a new solid-phase synthesis was designed. This synthesis was used for the preparation of a small library of platinum compounds. Several compounds from this library revealed promising activity during a cytotoxicity screen. Two active compounds were, therefore, synthesised on a larger scale and tested more extensively against a larger panel of cell-lines, confirming their high potential as antitumour compounds. The work presented illustrates how a combination of a new methodology and established techniques can speed up the search for platinum complexes with improved cytotoxic profiles compared to cisplatin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 99, Issue 10, October 2005, Pages 2032–2038
نویسندگان
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