Effects of tethered ligands and of metal oxidation state on the interactions of cobalt complexes with the 26S proteasome

Three cobalt complexes [CoII(L1)2] (1), [CoII(L2)] (2), and [CoIII(L1)2]ClO4 (3) were synthesized, characterized, and evaluated as potential agents for 26S proteasome inhibition in PC-3 cancer cells. Effects of ligand tethering and metal oxidation state are discussed.