کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1317928 | 976609 | 2010 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis, anticancer activities, interaction with DNA and mitochondria of manganese complexes Synthesis, anticancer activities, interaction with DNA and mitochondria of manganese complexes](/preview/png/1317928.png)
Two new complexes [(Etdpa)MnCl2] and [(Adpa)Mn(Cl)(H2O)] (Etdpa = ethyl bis(2-pyridylmethyl)amino-2-propionate; Adpa = bis(2-pyridylmethyl)amino-2-propionic acid) were synthesized and characterized by spectral methods. The crystal structure of [(Etdpa)MnCl2] shows that the Mn(II) atom is coordinated by three N atoms (N1, N2, N3), one oxygen atom (O1) of the ligand (Etdpa) and two chloride atoms (Cl1, Cl2), forming a distorted octahedral geometry. The binding interaction between ct-DNA and the synthesized complexes was relatively weak, but they can inhibit the induced swelling of Ca2+-loaded mitochondria in a dose-dependent manner. The [(Adpa)Mn(Cl)(H2O)] can cause the obvious decrease of mitochondria membrane potential. The MTT (3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenpyltetra-zolium bromide) assay shows that the two Mn(II) complexes are more active against cancer cells. Especially [(Adpa)Mn(Cl)(H2O)] can inhibit the proliferation of glioma cells with IC50 9.5 μM. Experimental results indicate that the [(Adpa)Mn(Cl)(H2O)] could be a new potential antitumor complex to target the mitochondria.
The manganese (II) complexes of bis(2-pyridylmethyl)amino-2-propionic acid) were synthesized and characterized by spectral methods. The complex can cause the obvious decrease of mitochondria membrane potential and can inhibit the proliferation of glioma cells with IC50 9.5 μM. Experimental results indicate that the [(Adpa)Mn(Cl)(H2O)] could be a new potential antitumor complex to target the mitochondria.Figure optionsDownload as PowerPoint slide
Journal: Journal of Inorganic Biochemistry - Volume 104, Issue 11, November 2010, Pages 1141–1147