کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1318116 976657 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solution equilibria of copper(II) complexation with N,N′-(2,2′-azanediylbis(ethane-2,1-diyl))dipicolinamide: A bio-distribution and dermal absorption study
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Solution equilibria of copper(II) complexation with N,N′-(2,2′-azanediylbis(ethane-2,1-diyl))dipicolinamide: A bio-distribution and dermal absorption study
چکیده انگلیسی
The protonation equilibria of a pentadentate ligand, N,N′-(2,2′-azanediylbis(ethane-2,1-diyl))dipicolinamide ([H2(5555)-N]) and the complexation of this ligand with Cu(II) Ca(II), Zn(II) and Ni(II) have been studied by pH-potentiometry, 1H NMR spectroscopy and UV-vis spectrophotometry. 1H NMR detected the protonation of the pyridyl groups and formation of Cu[H2(5555)-N]H species at low pH, while amide group deprotonation at higher pH resulted in the formation of Cu[H2(5555)-N]H−1 and Cu[H2(5555)-N]H−2 species in solution. Potentiometric detection of protonated species was limited by the acidic nature of the pyridyl nitrogen donors. From UV-vis spectroscopy it is suggested that the amide nitrogens are coordinated. This conclusion is supported by Molecular Mechanics calculations. Water-octanol partition coefficients for the Cu(II)-[H2(5555)-N] system indicated that although the Cu[H2(5555)-N]H−1 species is largely hydrophilic, approximately 54% of the complex goes into the organic phase. This percentage is able to promote dermal absorption of copper with a calculated penetration rate of 1.92 × 10−1 cm h−1. This was confirmed by dermal absorption studies which illustrate the role of hydrophobicity in promoting percutaneous drug administration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 101, Issue 8, August 2007, Pages 1120-1128
نویسندگان
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