Suzuki, Heck, and copper-free Sonogashira reactions catalyzed by 4-amino-5-methyl-3-thio-1,2,4-triazole-functionalized polystyrene resin-supported Pd(II) under aerobic conditions in water

4-amino-5-methyl-3-thio-1,2,4-triazole-functionalized polystyrene resin-supported Pd(II) complex was found to be an efficient catalyst in the palladium-catalyzed Suzuki–Miyaura coupling reactions of aryliodides and bromides, Mizoroki–Heck reactions of aryliodides and bromides, and copper-free Sonogashira reactions of aryliodides and bromides in water. Under appropriate conditions, all of these reactions give the desired products in moderate to excellent yields. The catalyst is air-stable and easily available. The palladium catalyst is easily separated, and can be reused for several times without a significant loss in its catalytic activity.

Triazole-functionalized polystyrene-supported Pd(II) complex was found to be an efficient catalyst in the palladium-catalyzed Suzuki, Heck, and Sonogashira reactions of aryl halides in water.Figure optionsDownload as PowerPoint slideHighlights
► The catalyst was prepared by immobilization of palladium complex on polystyrene and was fully characterized.
► The catalyst exhibited efficient catalytic activity in Suzuki, Heck, and Sonogashira reactions under aerobic condition.
► The catalyst can be reused several times without a noticeable change in activity.