New iron(II) cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leukemia cancer cells

• Five new iron(II) piano stool structured complexes.
• Crystallization in the monoclinic P21/c and monoclinic P21/n space groups.
• AFM images show strong and different types of interaction with pBR322 DNA plasmid.
• Cytotoxicity against human leukemia cancer cells (HL-60).
• Best cytotoxic activity for compound bearing 2-quinolinecarbonitrile ligand.

A new family of “FeII(η5-C5H5)” half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UV–Vis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P21/c and monoclinic P21/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin.

New organometallic half sandwich Fe(II)Cp compounds bearing a coordinated nitrile group bonded to one or two N-heteroaromatic rings. IC50 values for HL-60 leukemia cancer cells and AFM images of the interaction with pBR322 DNA revealing interesting cytotoxic behavior.Figure optionsDownload as PowerPoint slide