کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1324202 | 977327 | 2010 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Structural characterization of triorganotin(IV) complexes with sodium fusidate and DFT calculations Structural characterization of triorganotin(IV) complexes with sodium fusidate and DFT calculations](/preview/png/1324202.png)
Three new complexes of the steroid sodium fusidate (sodium 2-[(1S,2S,5R,6S,7S,10S,11S,13S, 14Z,15R,17R)-13-(acetyloxy)-5,17-dihydroxy-2,6,10,11-tetramethyl tetracyclo[8.7.0.02,7.011,15] heptadecan-14-ylidene]-6-methylhept-5-enoate = (NaFusidate, NaFA)]), with triorganotin(IV) moieties have been prepared and investigated by conventional techniques as FTIR, Mössbauer, ESI-MS and NMR spectroscopy. The isolated compounds showed stoichiometries organotin(IV)/fusidate 1/1, R3Sn(IV)FA (R = Me, FA1; Bu, FA2; Ph, FA3). The ligand coordination sites were determined by FTIR spectroscopic measurements. In the complexes, the carboxylate group of the fusidate ligand behaves as monodentate monoanionic donor, binding the Sn(IV) through one oxygen atom.On the basis of C–Sn–OCOO angles, calculated through the rationalization of the 119Sn Mössbauer parameter nuclear quadrupole splitting, it has been confirmed that, in all the solid state complexes, the Sn(IV) was tetracoordinated in a distorted tetrahedral structure.Further data from 119Sn CP-MAS spectra confirmed the distorted tetrahedral arrangement.In MeOH solution, 1H, 13C and 119Sn NMR spectroscopy showed monomeric complexes, where the carboxylate group mainly acts as monodentate ester-type ligand, and the occurrence of a coordinated solvent molecule to the tin center, as validated by non-relativistic NMR DFT study.
Three new complexes of the steroid sodium fusidate with triorganotin(IV) moieties have been prepared and investigated by conventional techniques as FTIR, Mössbauer, ESI-MS and NMR spectroscopies. The isolated compounds showed stoichiometries organotin(IV)/fusidate 1:1, R3Sn(IV)FA (R = Me, FA1; Bu, FA2; Ph, FA3). In the complexes, the carboxylate group of the fusidate ligand behaves as monodentate monoanionic donor binding the Sn(IV) through the oxygen atom in a somehow distorted tetrahedral structure.119Sn CP-MAS data confirmed the distorted tetrahedral arrangement.In MeOH solution, 1H, 13C and 119Sn NMR spectroscopy showed monomeric complexes, where the carboxylate group mainly acts as monodentate ester-type ligand, and the occurrence of a coordinated solvent molecule to the tin center, as validated by non-relativistic NMR DFT study.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 695, Issue 9, 1 May 2010, Pages 1405–1413