Cytotoxic benzophenone and triterpene from Garcinia hombroniana

• Fifteen compounds were isolated from Garcinia hombroniana.
• Compounds 1 and 9 induced DBTRG cells death.
• Compounds 1–8 exhibited strong antioxidant activities.

Garcinia hombroniana (seashore mangosteen) in Malaysia is used to treat itching and as a protective medicine after child birth. This study was aimed to investigate the bioactive chemical constituents of the bark of G. hombroniana. Ethyl acetate and dichloromethane extracts of G. hombroniana yielded two new (1, 9) and thirteen known compounds which were characterized by the spectral techniques of NMR, UV, IR and EI/ESI-MS, and identified as; 2,3′,4,5′-tetrahydroxy-6-methoxybenzophenone (1), 2,3′,4,4′-tetrahydroxy-6-methoxybenzophenone (2), 2,3′,4,6-tetrahydroxybenzophenone (3), 1,3,6,7-tetrahydroxyxanthone (4), 3,3′,4′,5,7-pentahydroxyflavone (5), 3,3′,5,5′,7-pentahydroxyflavanone (6), 3,3′,4′,5,5′,7-hexahydroxyflavone (7), 4′,5,7-trihydroxyflavanone-7-rutinoside (8), 18(13 → 17)-abeo-3β-acetoxy-9α,13β-lanost-24E-en-26-oic acid (9), garcihombronane B (10), garcihombronane D (11), friedelan-3-one (12), lupeol (13), stigmasterol (14) and stigmasterol glucoside (15). In the in vitro cytotoxicity against MCF-7, DBTRG, U2OS and PC-3 cell lines, compounds 1 and 9 displayed good cytotoxic effects against DBTRG cancer cell lines. Compounds 1–8 were also found to possess significant antioxidant activities. Owing to these properties, this study can be further extended to explore more significant bioactive components of this plant.

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