کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1356078 | 1500458 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, biological evaluation and molecular modeling study of pyrazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
• Pyrazole derivatives were synthesized.
• In vivo anti-inflammatory activity was evaluated.
• Carrageenan-induced rat paw edema model was used.
• In silico (docking) studies were carried out.
• Theoretical binding was calculated on schrodinger software.
A novel series of pyrazole derivatives were synthesized and evaluated in vivo for their anti-inflammatory activity in carrageenan-induced rat paw edema model. Among all compounds, 5a, and 5b showed comparable anti-inflammatory activity to Nimesulide, the standard drug taken for the studies. In silico (docking) studies were carried out to investigate the theoretical binding mode of the compounds to target the cyclooxygenase (COX-2) using Autodock 4.2.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic Chemistry - Volume 56, October 2014, Pages 8–15
Journal: Bioorganic Chemistry - Volume 56, October 2014, Pages 8–15
نویسندگان
Ashish Kumar Tewari, Ved Prakash Singh, Pratima Yadav, Garima Gupta, Amit Singh, Raj Kumar Goel, Pravin Shinde, C. Gopi Mohan,